How long does Semaglutide
stay in your system?

Semaglutide is the active ingredient in Ozempic, Wegovy, and the oral tablet Rybelsus. Its roughly 7-day half-life comes from a molecular design that binds albumin in the blood, slowing kidney clearance enough to support once-weekly injection.

Because the half-life is about a week, a meaningful amount of any single dose remains for several weeks. On a steady weekly schedule, semaglutide accumulates toward a stable baseline over four to five weeks; this single-dose calculation shows how one injection decays, not your full accumulated level on ongoing treatment.